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Molecules 2009, 14(12), 5349-5361; doi:10.3390/molecules14125349

Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui)

* ,
School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine 510405, Guangzhou, China
* Author to whom correspondence should be addressed.
Received: 30 October 2009 / Revised: 4 December 2009 / Accepted: 14 December 2009 / Published: 21 December 2009
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Radix Angelicae Sinensisis (RAS) is one of the most popular traditional Chinese herbal medicines. In the present study, six RAS extracts (i.e., phenolic extract PE, petroleum ether extract PEE, ethyl acetate extract EAE, absolute ethanol extract AEE, 95% ethanol extract 95 EE, and water extract WE) were prepared and their antioxidant activities measured by DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS [2,2′-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid diammonium salt)], Reducing power, •O2– and lipid peroxidation assays. In general, PE, PEE and EAE had relatively high antioxidant activity, followed by AEE with moderate activity, as compared with 95 EE and WE that had low activity. Their phenolic contents (including total phenolic, ferulic acid, caffeic acid, same as below) were then determined by HPLC or spectrophotometry. The sequence of phenolic contents was roughly identical with that of antioxidant activity. When the values of 1/IC50 of various antioxidant assays were used to evaluate the level of antioxidant of the RAS extracts, (plot between 1/IC50 values and phenolic contents), the correlation coefficient (R) ranged from 0.642 to 0.941, with an average value of 0.839. Significant positive correlations demonstrated that the antioxidant effects of RAS might generally be considered a result of the presence of the phenolic compounds, especially ferulic acid and caffeic acid.
Keywords: Radix Angelicae Sinensis; antioxidant; phenolic; correlation Radix Angelicae Sinensis; antioxidant; phenolic; correlation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, X.; Wu, X.; Huang, L. Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui). Molecules 2009, 14, 5349-5361.

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