Antimalarial Activity of Ultra-Short Peptides†
AbstractUltra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.
Share & Cite This Article
Pérez-Picaso, L.; Velasco-Bejarano, B.; Aguilar-Guadarrama, A.B.; Argotte-Ramos, R.; Rios, M.Y. Antimalarial Activity of Ultra-Short Peptides. Molecules 2009, 14, 5103-5114.
Pérez-Picaso L, Velasco-Bejarano B, Aguilar-Guadarrama AB, Argotte-Ramos R, Rios MY. Antimalarial Activity of Ultra-Short Peptides. Molecules. 2009; 14(12):5103-5114.Chicago/Turabian Style
Pérez-Picaso, Lemuel; Velasco-Bejarano, Benjamín; Aguilar-Guadarrama, A. Berenice; Argotte-Ramos, Rocío; Rios, María Yolanda. 2009. "Antimalarial Activity of Ultra-Short Peptides." Molecules 14, no. 12: 5103-5114.