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Antimalarial Activity of Ultra-Short Peptides†
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, México
Instituto Nacional de Salud Pública, Centro de Investigación Sobre Enfermedades Infecciosas (CISEI), Avenida Universidad 655, Col. Santa María Ahuacatitlán, 62100 Cuernavaca, Morelos, México
† This paper is taken in part from the Ph.D. thesis of Lemuel Pérez-Picaso.
* Author to whom correspondence should be addressed.
Received: 18 November 2009; in revised form: 8 December 2009 / Accepted: 8 December 2009 / Published: 8 December 2009
Abstract: Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.
Keywords: tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides
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Pérez-Picaso, L.; Velasco-Bejarano, B.; Aguilar-Guadarrama, A.B.; Argotte-Ramos, R.; Rios, M.Y. Antimalarial Activity of Ultra-Short Peptides. Molecules 2009, 14, 5103-5114.
Pérez-Picaso L, Velasco-Bejarano B, Aguilar-Guadarrama AB, Argotte-Ramos R, Rios MY. Antimalarial Activity of Ultra-Short Peptides. Molecules. 2009; 14(12):5103-5114.
Pérez-Picaso, Lemuel; Velasco-Bejarano, Benjamín; Aguilar-Guadarrama, A. Berenice; Argotte-Ramos, Rocío; Rios, María Yolanda. 2009. "Antimalarial Activity of Ultra-Short Peptides." Molecules 14, no. 12: 5103-5114.