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Molecules 2009, 14(12), 5103-5114; doi:10.3390/molecules14125103
Article

Antimalarial Activity of Ultra-Short Peptides

1, 1, 1, 2 and 1,*
Received: 18 November 2009 / Revised: 8 December 2009 / Accepted: 8 December 2009 / Published: 8 December 2009
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Abstract

Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC50 data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC50 values of 3.31 and 2.57 μM, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.
Keywords: tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides tetrapeptides; antimalarial activity; Plasmodium berghei; ultra-short peptides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pérez-Picaso, L.; Velasco-Bejarano, B.; Aguilar-Guadarrama, A.B.; Argotte-Ramos, R.; Rios, M.Y. Antimalarial Activity of Ultra-Short Peptides. Molecules 2009, 14, 5103-5114.

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