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Molecules 2009, 14(11), 4779-4789; doi:10.3390/molecules14114779
Article

Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst

,  and *
Department of Chemistry and Biology, Lishui University, Lishui, Zhejiang 323000, China
* Author to whom correspondence should be addressed.
Received: 3 November 2009 / Revised: 19 November 2009 / Accepted: 23 November 2009 / Published: 23 November 2009
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Abstract

A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using silica sulfuric acid (SSA or SiO2-SO3H) was developed. This method is simple, convenient and the title compounds are produced in good to excellent yields.
Keywords: amines; thiols; silica sulfuric acid (SSA); Michael reaction; α,β-unsaturated olefins amines; thiols; silica sulfuric acid (SSA); Michael reaction; α,β-unsaturated olefins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, Y.; Yuan, Y.-Q.; Guo, S.-R. Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst. Molecules 2009, 14, 4779-4789.

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