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Molecules 2009, 14(11), 4779-4789; doi:10.3390/molecules14114779
Article

Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst

,  and *
Department of Chemistry and Biology, Lishui University, Lishui, Zhejiang 323000, China
* Author to whom correspondence should be addressed.
Received: 3 November 2009 / Revised: 19 November 2009 / Accepted: 23 November 2009 / Published: 23 November 2009
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Abstract

A highly efficient, inexpensive, recyclable, convenient, and green protocol for chemoselective aza-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using silica sulfuric acid (SSA or SiO2-SO3H) was developed. This method is simple, convenient and the title compounds are produced in good to excellent yields.
Keywords: amines; thiols; silica sulfuric acid (SSA); Michael reaction; α,β-unsaturated olefins amines; thiols; silica sulfuric acid (SSA); Michael reaction; α,β-unsaturated olefins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, Y.; Yuan, Y.-Q.; Guo, S.-R. Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst. Molecules 2009, 14, 4779-4789.

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