Njaoaminiums A, B, and C: Cyclic 3-Alkylpyridinium Salts from the Marine Sponge Reniera sp.
AbstractThree novel cyclic 3-alkylpyridinium salts, named njaoaminiums A, B, and C (1-3), were isolated from the marine sponge Reniera sp., collected off the coasts of Pemba Island, Tanzania. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Njaoaminiums B (2) and C (3) are the first examples of cyclic 3-alkylpyridinium salts bearing a methyl substituent on the alkyl chains. These compounds are assumed to be biosynthetic precursors of the njaoamines, previously isolated from the same sponge. The absolute configurations of the methyls of 2 and 3 were assigned by comparison between experimental and TDDFT calculated circular dichroism spectra on the most stable conformer. Compound 2 showed weak cytotoxicity against the three human tumor cell lines MDA-MB-231, A549, and HT29.
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Laville, R.; Genta-Jouve, G.; Urda, C.; Fernández, R.; Thomas, O.P.; Reyes, F.; Amade, P. Njaoaminiums A, B, and C: Cyclic 3-Alkylpyridinium Salts from the Marine Sponge Reniera sp.. Molecules 2009, 14, 4716-4724.
Laville R, Genta-Jouve G, Urda C, Fernández R, Thomas OP, Reyes F, Amade P. Njaoaminiums A, B, and C: Cyclic 3-Alkylpyridinium Salts from the Marine Sponge Reniera sp.. Molecules. 2009; 14(11):4716-4724.Chicago/Turabian Style
Laville, Remi; Genta-Jouve, Grégory; Urda, Carlos; Fernández, Rogelio; Thomas, Olivier P.; Reyes, Fernando; Amade, Philippe. 2009. "Njaoaminiums A, B, and C: Cyclic 3-Alkylpyridinium Salts from the Marine Sponge Reniera sp.." Molecules 14, no. 11: 4716-4724.