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Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species
Institute of Technical Biochemistry, Technical University of Łódź, ul. Stefanowskiego 4/10, 90-924 Łódź, Poland
Laboratory of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FI-20500 Abo, Finland
Laboratory of Wood and Paper Chemistry, Abo Akademi University, Porthansgatan 3, FI-20500 Abo, Finland
These authors contributed equally to this paper.
Current address: Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
* Author to whom correspondence should be addressed.
Received: 14 August 2009; in revised form: 2 October 2009 / Accepted: 14 October 2009 / Published: 16 October 2009
Abstract: X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the Dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.
Keywords: phenolic compounds; lignans; flavonoids; antioxidant potency; crystal structure; "host - guest" inclusion crystals
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Redzynia, I.; Ziółkowska, N.E.; Majzner, W.R.; Willför, S.; Sjöholm, R.; Eklund, P.; Bujacz, G.D. Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species. Molecules 2009, 14, 4147-4158.
Redzynia I, Ziółkowska NE, Majzner WR, Willför S, Sjöholm R, Eklund P, Bujacz GD. Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species. Molecules. 2009; 14(10):4147-4158.
Redzynia, Izabela; Ziółkowska, Natasza E.; Majzner, Wiesław R.; Willför, Stefan; Sjöholm, Rainer; Eklund, Patrik; Bujacz, Grzegorz D. 2009. "Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species." Molecules 14, no. 10: 4147-4158.