An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

doi:10.3390/molecules14103952

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Molecules 2009, 14(10), 3952-3963; doi:10.3390/molecules14103952

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An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

Chun-Wei Kuo, Chun-Chao Wang, Hu-Lin Fang, B. R. Raju, Veerababurao Kavala, Pateliya M. Habib and Ching-Fa Yao *

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 116, Taiwan

* Author to whom correspondence should be addressed.

Received: 25 August 2009; in revised form: 25 September 2009 / Accepted: 27 September 2009 / Published: 9 October 2009

(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)

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Abstract: An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

Keywords: indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation

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MDPI and ACS Style

Kuo, C.-W.; Wang, C.-C.; Fang, H.-L.; Raju, B.R.; Kavala, V.; Habib, P.M.; Yao, C.-F. An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes. Molecules 2009, 14, 3952-3963.

AMA Style

Kuo C.-W., Wang C.-C., Fang H.-L., Raju B.R., Kavala V., Habib P.M., Yao C.-F. An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes. Molecules. 2009; 14(10):3952-3963.

Chicago/Turabian Style

Kuo, Chun-Wei; Wang, Chun-Chao; Fang, Hu-Lin; Raju, B. R.; Kavala, Veerababurao; Habib, Pateliya M.; Yao, Ching-Fa. 2009. "An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes." Molecules 14, no. 10: 3952-3963.

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