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Molecules 2009, 14(10), 3952-3963; doi:10.3390/molecules14103952
Article

An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes

, , , , ,  and *
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 116, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 August 2009 / Revised: 25 September 2009 / Accepted: 27 September 2009 / Published: 9 October 2009
(This article belongs to the Special Issue Advances in Heteroaromatic Chemistry)
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Abstract

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.
Keywords: indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuo, C.-W.; Wang, C.-C.; Fang, H.-L.; Raju, B.R.; Kavala, V.; Habib, P.M.; Yao, C.-F. An Efficient Method for the N-Bromosuccinimide Catalyzed Synthesis of Indolyl-Nitroalkanes. Molecules 2009, 14, 3952-3963.

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