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Molecules 2009, 14(1), 573-583; doi:10.3390/molecules14010573
Article

Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts

1,2
, 2, 2, 2, 2, 2, 2,*  and 3,*
Received: 16 December 2008; in revised form: 17 January 2009 / Accepted: 22 January 2009 / Published: 23 January 2009
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Abstract: Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis.
Keywords: Morinda officinalis; Anthraquinones; Osteoblast; Osteoclast; Osteoporosis Morinda officinalis; Anthraquinones; Osteoblast; Osteoclast; Osteoporosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, Y.-B.; Zheng, C.-J.; Qin, L.-P.; Sun, L.-N.; Han, T.; Jiao, L.; Zhang, Q.-Y.; Wu, J.-Z. Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts. Molecules 2009, 14, 573-583.

AMA Style

Wu Y-B, Zheng C-J, Qin L-P, Sun L-N, Han T, Jiao L, Zhang Q-Y, Wu J-Z. Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts. Molecules. 2009; 14(1):573-583.

Chicago/Turabian Style

Wu, Yan-Bin; Zheng, Cheng-Jian; Qin, Lu-Ping; Sun, Lian-Na; Han, Ting; Jiao, Lei; Zhang, Qiao-Yan; Wu, Jin-Zhong. 2009. "Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts." Molecules 14, no. 1: 573-583.


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