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Molecules 2009, 14(1), 46-52; doi:10.3390/molecules14010046
Communication

Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis

1
, 2,* , 3
 and 4
Received: 26 November 2008; in revised form: 17 December 2008 / Accepted: 18 December 2008 / Published: 23 December 2008
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Abstract: In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: ΔHf (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and HBC (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained.
Keywords: Flavonoid; Structure-Activity Relationship; Quantum Chemistry; Antioxidant Flavonoid; Structure-Activity Relationship; Quantum Chemistry; Antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yang, J.-G.; Liu, B.-G.; Liang, G.-Z.; Ning, Z.-X. Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis. Molecules 2009, 14, 46-52.

AMA Style

Yang J-G, Liu B-G, Liang G-Z, Ning Z-X. Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis. Molecules. 2009; 14(1):46-52.

Chicago/Turabian Style

Yang, Ji-Guo; Liu, Ben-Guo; Liang, Gui-Zhao; Ning, Zheng-Xiang. 2009. "Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis." Molecules 14, no. 1: 46-52.


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