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Open AccessCommunication
Molecules 2009, 14(1), 46-52; doi:10.3390/molecules14010046

Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis

1
College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, P. R. China
2
School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, P. R. China
3
College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China
4
College of Light Industry and Food Science, South China University of Technology, Guangzhou 453003, P. R. China
*
Author to whom correspondence should be addressed.
Received: 26 November 2008 / Revised: 17 December 2008 / Accepted: 18 December 2008 / Published: 23 December 2008
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Abstract

In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: ΔHf (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and HBC (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained.
Keywords: Flavonoid; Structure-Activity Relationship; Quantum Chemistry; Antioxidant Flavonoid; Structure-Activity Relationship; Quantum Chemistry; Antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, J.-G.; Liu, B.-G.; Liang, G.-Z.; Ning, Z.-X. Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis. Molecules 2009, 14, 46-52.

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