Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke

doi:10.3390/molecules14010266

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Molecules 2009, 14(1), 266-272; doi:10.3390/molecules14010266

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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke

Ji Young Choi¹, MinKyun Na^1,* , In Hyun Hwang¹, Seung Ho Lee^1,* , Eun Young Bae², Bo Yeon Kim² and Jong Seog Ahn^2,*

¹ College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea ² Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoun-dong, Yuseong-gu, Daejeon 305-806, Korea

* Authors to whom correspondence should be addressed.

Received: 5 December 2008; in revised form: 26 December 2008 / Accepted: 4 January 2009 / Published: 8 January 2009

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Abstract: Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.

Keywords: Protein tyrosine phosphatase 1B; Saussurea lappa C.B.Clarke; Betulinic acid; Betulinic acid methyl ester; Mokko lactone; Dehydrocostuslactone

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Cite This Article

MDPI and ACS Style

Choi, J.Y.; Na, M.; Hyun Hwang, I.; Ho Lee, S.; Young Bae, E.; Yeon Kim, B.; Seog Ahn, J. Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke. Molecules 2009, 14, 266-272.

AMA Style

Choi J.Y., Na M., Hyun Hwang I., Ho Lee S., Young Bae E., Yeon Kim B., Seog Ahn J. Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke. Molecules. 2009; 14(1):266-272.

Chicago/Turabian Style

Choi, Ji Y.; Na, MinKyun; Hyun Hwang, In; Ho Lee, Seung; Young Bae, Eun; Yeon Kim, Bo; Seog Ahn, Jong. 2009. "Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappa C.B.Clarke." Molecules 14, no. 1: 266-272.

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