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Molecules 2008, 13(9), 2303-2312; doi:10.3390/molecules13092303
Communication

Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor

1, 2
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2
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1,*
1 Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA 2 Department of Pharmacology and Center for Substance Abuse Research, School of Medicine, Temple University, 3420 N. Broad St, Philadelphia, PA 19140, USA 3 Department of Pharmacology, University of North Carolina Medical School, Chapel Hill, NC 27599, USA 4 Center for Neurobiology Division of Medicinal Chemistry and Natural Products, and NIMH Psychoactive Drug Screening Program, University of North Carolina Medical School, Chapel Hill, NC 27599, USA
* Author to whom correspondence should be addressed.
Received: 29 August 2008 / Revised: 15 September 2008 / Accepted: 16 September 2008 / Published: 25 September 2008
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Abstract

Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D1 receptor. Isocorypalmine had the highest affinity (Ki = 83 nM). The structure-affinity relationships of these alkaloids are discussed.
Keywords: Corydalis yanhusuo; Isoquinoline alkaloids; d/l Ratio; Chiral HPLC; Dopamine receptor Corydalis yanhusuo; Isoquinoline alkaloids; d/l Ratio; Chiral HPLC; Dopamine receptor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ma, Z.-Z.; Xu, W.; Jensen, N.H.; Roth, B.L.; Liu-Chen, L.-Y.; Lee, D.Y.W. Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor. Molecules 2008, 13, 2303-2312.

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