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Molecules 2008, 13(9), 2313-2325; doi:10.3390/molecules13092313
Article

Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

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Received: 22 August 2008 / Revised: 10 September 2008 / Accepted: 10 September 2008 / Published: 25 September 2008
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Abstract

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
Keywords: Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuo, C.-W.; Wang, C.-C.; Kavala, V.; Yao, C.-F. Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions. Molecules 2008, 13, 2313-2325.

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