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Molecules 2008, 13(9), 2313-2325; doi:10.3390/molecules13092313
Article

Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

, ,  and *
Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC
* Author to whom correspondence should be addressed.
Received: 22 August 2008 / Revised: 10 September 2008 / Accepted: 10 September 2008 / Published: 25 September 2008
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Abstract

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.
Keywords: Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kuo, C.-W.; Wang, C.-C.; Kavala, V.; Yao, C.-F. Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions. Molecules 2008, 13, 2313-2325.

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