Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

doi:10.3390/molecules13092313

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Molecules 2008, 13(9), 2313-2325; doi:10.3390/molecules13092313

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Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

Chun-Wei Kuo, Chun-Chao Wang, Veerababurao Kavala and Ching-Fa Yao*

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, ROC

* Author to whom correspondence should be addressed.

Received: 22 August 2008; in revised form: 10 September 2008 / Accepted: 10 September 2008 / Published: 25 September 2008

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Abstract: 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

Keywords: Benzodiazepines; 2; 4; 6-trichloro-1; 3; 5-triazine; enolizable ketones; o-phenylenediamines

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MDPI and ACS Style

Kuo, C.-W.; Wang, C.-C.; Kavala, V.; Yao, C.-F. Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions. Molecules 2008, 13, 2313-2325.

AMA Style

Kuo C-W, Wang C-C, Kavala V, Yao C-F. Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions. Molecules. 2008; 13(9):2313-2325.

Chicago/Turabian Style

Kuo, Chun-Wei; Wang, Chun-Chao; Kavala, Veerababurao; Yao, Ching-Fa. 2008. "Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions." Molecules 13, no. 9: 2313-2325.

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