Synthesis of an ent-Halimanolide from ent-Halimic Acid

doi:10.3390/molecules13051120

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Molecules 2008, 13(5), 1120-1134; doi:10.3390/molecules13051120

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Synthesis of an ent-Halimanolide from ent-Halimic Acid

Isidro S. Marcos^1,* , Almudena Conde¹, Rosalina F. Moro¹, Pilar Basabe¹, David Díez¹, Faustino Mollinedo^2,3 and Julio G. Urones¹

¹ Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain ² Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, Campus Miguel de Unamuno, E-37007 Salamanca, Spain ³ APOINTECH, Campus Miguel de Unamuno, E-37007 Salamanca, Spain

* Author to whom correspondence should be addressed.

Received: 28 April 2008; in revised form: 7 May 2008 / Accepted: 7 May 2008 / Published: 9 May 2008

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Abstract: An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2β-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.

Keywords: Ent-halimanolides; ent-halimic acid; diterpenoids; Cladogynos orientalis.

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MDPI and ACS Style

Marcos, I.S.; Conde, A.; Moro, R.F.; Basabe, P.; Díez, D.; Mollinedo, F.; Urones, J.G. Synthesis of an ent-Halimanolide from ent-Halimic Acid. Molecules 2008, 13, 1120-1134.

AMA Style

Marcos IS, Conde A, Moro RF, Basabe P, Díez D, Mollinedo F, Urones JG. Synthesis of an ent-Halimanolide from ent-Halimic Acid. Molecules. 2008; 13(5):1120-1134.

Chicago/Turabian Style

Marcos, Isidro S.; Conde, Almudena; Moro, Rosalina F.; Basabe, Pilar; Díez, David; Mollinedo, Faustino; Urones, Julio G. 2008. "Synthesis of an ent-Halimanolide from ent-Halimic Acid." Molecules 13, no. 5: 1120-1134.

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