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A Convenient Synthesis of Amino Acid Methyl Esters
The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
* Author to whom correspondence should be addressed.
Received: 29 April 2008; in revised form: 5 May 2008 / Accepted: 6 May 2008 / Published: 8 May 2008
Abstract: A series of amino acid methyl ester hydrochlorides were prepared in good toexcellent yields by the room temperature reaction of amino acids with methanol in thepresence of trimethylchlorosilane. This method is not only compatible with natural aminoacids, but also with other aromatic and aliphatic amino acids.
Keywords: Amino acid methyl ester hydrochlorides; amino acids; trimethylchlorosilane; esterification
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Cite This Article
MDPI and ACS Style
Li, J.; Sha, Y. A Convenient Synthesis of Amino Acid Methyl Esters. Molecules 2008, 13, 1111-1119.
Li J, Sha Y. A Convenient Synthesis of Amino Acid Methyl Esters. Molecules. 2008; 13(5):1111-1119.
Li, Jiabo; Sha, Yaowu. 2008. "A Convenient Synthesis of Amino Acid Methyl Esters." Molecules 13, no. 5: 1111-1119.