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Open AccessCommunication
Molecules 2008, 13(5), 1111-1119; doi:10.3390/molecules13051111

A Convenient Synthesis of Amino Acid Methyl Esters

The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
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Received: 29 April 2008 / Revised: 5 May 2008 / Accepted: 6 May 2008 / Published: 8 May 2008
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Abstract

A series of amino acid methyl ester hydrochlorides were prepared in good toexcellent yields by the room temperature reaction of amino acids with methanol in thepresence of trimethylchlorosilane. This method is not only compatible with natural aminoacids, but also with other aromatic and aliphatic amino acids.
Keywords: Amino acid methyl ester hydrochlorides; amino acids; trimethylchlorosilane; esterification Amino acid methyl ester hydrochlorides; amino acids; trimethylchlorosilane; esterification
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, J.; Sha, Y. A Convenient Synthesis of Amino Acid Methyl Esters. Molecules 2008, 13, 1111-1119.

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