Next Article in Journal
Cytoprotective Efficacy of Amifostine Against Radiation- Induced Rectal Toxicity: Objective and Subjective Grading Scales for Radiomucositis
Previous Article in Journal
Development of an Enzyme-linked Immuno-Sorbent Assay (ELISA) Method for Carbofuran Residues
Article Menu

Export Article

Open AccessArticle
Molecules 2008, 13(4), 882-891; doi:10.3390/molecules13040822

A Structure-Activity Study of Antibacterial Diterpenoids

Facultad de Química y Biología, Casilla 40, Correo 33, Universidad de Santiago de Chile, Santiago, Chile
*
Author to whom correspondence should be addressed.
Received: 28 March 2008 / Revised: 16 April 2008 / Accepted: 17 April 2008 / Published: 17 April 2008
View Full-Text   |   Download PDF [573 KB, uploaded 18 June 2014]   |  

Abstract

An analysis of the antibacterial activities of 15 terpenoids, eleven of which werepreviously described by us and four were extracted from the literature, suggested twostructural requirements for activity of these and related compounds: a hydrophobic moiety,consisting of a substituted decalin skeleton, and a hydrophilic region possessing onehydrogen-bond-donor group. These structural requirements are responsible for an optimalinsertion of these and related compounds into cell membranes, as suggested by the resultsof docking some of these compounds into a model phospholipid bilayer.
Keywords: Diterpenoids; antibacterial activity; structural requirements; phospholipid bilayer; docking Diterpenoids; antibacterial activity; structural requirements; phospholipid bilayer; docking
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Urzúa, A.; Rezende, M.C.; Mascayano, C.; Vásquez, L. A Structure-Activity Study of Antibacterial Diterpenoids. Molecules 2008, 13, 882-891.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top