A Structure-Activity Study of Antibacterial Diterpenoids
AbstractAn analysis of the antibacterial activities of 15 terpenoids, eleven of which werepreviously described by us and four were extracted from the literature, suggested twostructural requirements for activity of these and related compounds: a hydrophobic moiety,consisting of a substituted decalin skeleton, and a hydrophilic region possessing onehydrogen-bond-donor group. These structural requirements are responsible for an optimalinsertion of these and related compounds into cell membranes, as suggested by the resultsof docking some of these compounds into a model phospholipid bilayer. View Full-Text
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Urzúa, A.; Rezende, M.C.; Mascayano, C.; Vásquez, L. A Structure-Activity Study of Antibacterial Diterpenoids. Molecules 2008, 13, 882-891.
Urzúa A, Rezende MC, Mascayano C, Vásquez L. A Structure-Activity Study of Antibacterial Diterpenoids. Molecules. 2008; 13(4):882-891.Chicago/Turabian Style
Urzúa, Alejandro; Rezende, Marcos C.; Mascayano, Carolina; Vásquez, Loretta. 2008. "A Structure-Activity Study of Antibacterial Diterpenoids." Molecules 13, no. 4: 882-891.