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Molecules 2008, 13(12), 3069-3076; doi:10.3390/molecules13123069
Article

Effects of Two Terpene Alcohols on the Antibacterial Activity and the Mode of Action of Farnesol against Staphylococcus aureus

1, 2,* , 1 and 3
Received: 14 October 2008; in revised form: 20 November 2008 / Accepted: 3 December 2008 / Published: 9 December 2008
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Abstract: We have studied changes in the antibacterial activity and the mode of action of farnesol against Staphylococcus aureus when two terpene alcohols with an aliphatic carbon chain were added, individually, to a bacterial suspension that contained farnesol. Geraniol increased the growth-inhibitory activity of farnesol, but suppressed its ability to damage cell membranes, which is one of the predominant features of the growth-inhibitory activity of farnesol. Geranylgeraniol decreased the growth-inhibitory activity of farnesol and also suppressed its cell-damaging activity. It is possible that the presence of a terpene alcohol can both enhance and suppress the antibacterial activity of farnesol, and even change its mode of action. Thus, it is important to study not only the antibacterial activity of each constituent of an essential oil but also the interactions between them in efforts to characterize the antibacterial activity of the essential oil.
Keywords: Terpene alcohol; Antibacterial activity; Staphylococcus aureus; Cell membrane Terpene alcohol; Antibacterial activity; Staphylococcus aureus; Cell membrane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Togashi, N.; Inoue, Y.; Hamashima, H.; Takano, A. Effects of Two Terpene Alcohols on the Antibacterial Activity and the Mode of Action of Farnesol against Staphylococcus aureus. Molecules 2008, 13, 3069-3076.

AMA Style

Togashi N, Inoue Y, Hamashima H, Takano A. Effects of Two Terpene Alcohols on the Antibacterial Activity and the Mode of Action of Farnesol against Staphylococcus aureus. Molecules. 2008; 13(12):3069-3076.

Chicago/Turabian Style

Togashi, Naoko; Inoue, Yoshihiro; Hamashima, Hajime; Takano, Akihito. 2008. "Effects of Two Terpene Alcohols on the Antibacterial Activity and the Mode of Action of Farnesol against Staphylococcus aureus." Molecules 13, no. 12: 3069-3076.



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