Molecules 2008, 13(12), 2925-2934; doi:10.3390/molecules13122925

Cytotoxic Steroidal Saponins from the Flowers of Allium leucanthum

1email, 3email, 3email, 3email, 1, 2email and 3,* email
Received: 1 October 2008; in revised form: 17 November 2008 / Accepted: 24 November 2008 / Published: 26 November 2008
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Allium leucanthum C. Koch is an endemic Caucasian species that grows in Georgia. The flowers are used in traditional medicine. Phytochemical investigation allowed the isolation of seven spirostanol type saponins from the flowers. Their structures were elucidated on the base of NMR and HRESIMS spectrometry data. A new compound, which we have named leucospiroside A (5), has been identified as (25R)-5α-spirostane-2α,3β,6β-triol 3-O-β-glucopyranosyl-(1→3)-β-glucopyranosyl-(1→2)-[β-glucopyranosyl-(1→3)]-β-glucopyranosyl-(1→4)-β-galactopyranoside. The six others were known substances, but are described in this plant for the first time. The crude extract, spirostanol and furostanol fractions, as well as isolated compounds, were evaluated for their in vitro cytotoxic activity. Compounds 1-3 and 5 were found to be the most active, with relatively similar IC50 values ranging from 3.7 to 5.8 μM for a lung cancer cell line (A549) and 5.6 to 8.2 μM for a colon cancer cell line (DLD-1).
Keywords: Allium leucathum; Spirostane saponins; Structure determination; Cytotoxic activity
PDF Full-text Download PDF Full-Text [221 KB, uploaded 18 June 2014 19:28 CEST]

Export to BibTeX |

MDPI and ACS Style

Mskhiladze, L.; Legault, J.; Lavoie, S.; Mshvildadze, V.; Kuchukhidze, J.; Elias, R.; Pichette, A. Cytotoxic Steroidal Saponins from the Flowers of Allium leucanthum. Molecules 2008, 13, 2925-2934.

AMA Style

Mskhiladze L, Legault J, Lavoie S, Mshvildadze V, Kuchukhidze J, Elias R, Pichette A. Cytotoxic Steroidal Saponins from the Flowers of Allium leucanthum. Molecules. 2008; 13(12):2925-2934.

Chicago/Turabian Style

Mskhiladze, Lasha; Legault, Jean; Lavoie, Serge; Mshvildadze, Vakhtang; Kuchukhidze, Jumber; Elias, Riad; Pichette, André. 2008. "Cytotoxic Steroidal Saponins from the Flowers of Allium leucanthum." Molecules 13, no. 12: 2925-2934.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert