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Molecules 2008, 13(11), 2915-2924; doi:10.3390/molecules13112915

A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata

1 Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 0824-00172,Panama 2 Departamento de Química Farmacéutica, Facultad de Farmacia, CIETUS, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007, Salamanca, Spain
* Author to whom correspondence should be addressed.
Received: 16 October 2008 / Revised: 14 November 2008 / Accepted: 18 November 2008 / Published: 25 November 2008
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Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI50 values from 1.2 to 3.3 μg/mL.
Keywords: Marila pluricostata; Clusiaceae; Triterpenoids; Cytotoxicity; 2α; 3β- dihydroxy-D:A-friedoolean-28-oic acid Marila pluricostata; Clusiaceae; Triterpenoids; Cytotoxicity; ; 3β- dihydroxy-D:A-friedoolean-28-oic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Olmedo, D.A.; López-Pérez, J.L.; Del Olmo, E.; Vásquez, Y.; San Feliciano, A.; Gupta, M.P. A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata. Molecules 2008, 13, 2915-2924.

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