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Antiparkinson Prodrugs
Molecules 2008, 13(1), 96-106; doi:10.3390/molecules13010096

Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin

* ,
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 16 January 2008 / Accepted: 16 January 2008 / Published: 18 January 2008
(This article belongs to the Special Issue Prodrugs)
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Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies.
Keywords: aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs; aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs;
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sobczak, M.; Witkowska, E.; Olędzka, E.; Kolodziejski, W. Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin. Molecules 2008, 13, 96-106.

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