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Antiparkinson Prodrugs
Molecules 2008, 13(1), 96-106; doi:10.3390/molecules13010096
Article

Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin

* ,
,
 and
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 16 January 2008 / Accepted: 16 January 2008 / Published: 18 January 2008
(This article belongs to the Special Issue Prodrugs)
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Abstract

Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies.
Keywords: aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs; aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs;
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sobczak, M.; Witkowska, E.; Olędzka, E.; Kolodziejski, W. Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin. Molecules 2008, 13, 96-106.

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