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Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 14 December 2007; in revised form: 16 January 2008 / Accepted: 16 January 2008 / Published: 18 January 2008
(This article belongs to the Special Issue Prodrugs
Abstract: Two-, three- and four-arm, star-shaped poly(ε-caprolactone) andpoly(D,L-lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide weresynthesized via ring-opening polymerization of cyclic esters in the presence of glycerol,penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst.Thus obtained oligomers were successfully used in the synthesis of novel macromolecularprodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated bymeans of MALDI-TOF MS, NMR and IR studies.
Keywords: aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs;
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Sobczak, M.; Witkowska, E.; Olędzka, E.; Kolodziejski, W. Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin. Molecules 2008, 13, 96-106.
Sobczak M, Witkowska E, Olędzka E, Kolodziejski W. Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin. Molecules. 2008; 13(1):96-106.
Sobczak, Marcin; Witkowska, Ewa; Olędzka, Ewa; Kolodziejski, Waclaw. 2008. "Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin." Molecules 13, no. 1: 96-106.