Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa
AbstractUsing a bioactivity-guided fractionation method, two coumarins: minumicrolineacetonide (1) and epimurpaniculol senecioate (2), were isolated from the leaves ofMurraya omphalocarpa Hayata (Rutaceae). Compound 1 had been previously synthesizedand was now isolated from natural sources for the first time, and compound 2, possessing anegative optical rotation value, is new. The structures and their stereochemistry were fullyelucidated on the basis of spectroscopic and X-ray crystallographic techniques. Bothcompounds 1 and 2 are active in the antiplatelet aggregation assay. Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF). View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Chia, Y.-C.; Chang, F.-R.; Wang, J.-C.; Wu, C.-C.; Chiang, M.Y.-N.; Lan, Y.-H.; Chen, K.-S.; Wu, Y.-C. Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa. Molecules 2008, 13, 122-128.
Chia Y-C, Chang F-R, Wang J-C, Wu C-C, Chiang MY-N, Lan Y-H, Chen K-S, Wu Y-C. Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa. Molecules. 2008; 13(1):122-128.Chicago/Turabian Style
Chia, Yi-Chen; Chang, Fang-Rong; Wang, Jinn-Chyi; Wu, Chin-Chung; Chiang, Michael Y.-N.; Lan, Yu-Hsuan; Chen, Keh-Shaw; Wu, Yang-Chang. 2008. "Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa." Molecules 13, no. 1: 122-128.