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Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa
Department of Food Science and Technology, Ta-Jen University, Ping Tung Hsien, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 20 November 2007; in revised form: 7 January 2008 / Accepted: 7 January 2008 / Published: 21 January 2008
Abstract: Using a bioactivity-guided fractionation method, two coumarins: minumicrolineacetonide (1) and epimurpaniculol senecioate (2), were isolated from the leaves ofMurraya omphalocarpa Hayata (Rutaceae). Compound 1 had been previously synthesizedand was now isolated from natural sources for the first time, and compound 2, possessing anegative optical rotation value, is new. The structures and their stereochemistry were fullyelucidated on the basis of spectroscopic and X-ray crystallographic techniques. Bothcompounds 1 and 2 are active in the antiplatelet aggregation assay. Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF).
Keywords: Murraya omphalocarpa; coumarin; epimurpaniculol senecioate; X-ray;
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Chia, Y.-C.; Chang, F.-R.; Wang, J.-C.; Wu, C.-C.; Chiang, M.Y.-N.; Lan, Y.-H.; Chen, K.-S.; Wu, Y.-C. Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa. Molecules 2008, 13, 122-128.
Chia Y-C, Chang F-R, Wang J-C, Wu C-C, Chiang MY-N, Lan Y-H, Chen K-S, Wu Y-C. Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa. Molecules. 2008; 13(1):122-128.
Chia, Yi-Chen; Chang, Fang-Rong; Wang, Jinn-Chyi; Wu, Chin-Chung; Chiang, Michael Y.-N.; Lan, Yu-Hsuan; Chen, Keh-Shaw; Wu, Yang-Chang. 2008. "Antiplatelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa." Molecules 13, no. 1: 122-128.