New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

doi:10.3390/12082029

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Molecules 2007, 12(8), 2029-2037; doi:10.3390/12082029

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New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

Lan-Lan Xu¹, Kun Zou^1,* , Jun-Zhi Wang¹, Jun Wu², Yuan Zhou¹, Fei-Jun Dan¹ and Jing Yang¹

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Received: 8 June 2007; in revised form: 11 July 2007 / Accepted: 12 July 2007 / Published: 23 August 2007

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract: Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,7α,22ξ,26- octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.

Keywords: Furostanol Saponins; Tupistra chinensis Bak.; Liliaceae; Convallarieae; NO

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MDPI and ACS Style

Xu, L.-L.; Zou, K.; Wang, J.-Z.; Wu, J.; Zhou, Y.; Dan, F.-J.; Yang, J. New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes. Molecules 2007, 12, 2029-2037.

AMA Style

Xu L-L, Zou K, Wang J-Z, Wu J, Zhou Y, Dan F-J, Yang J. New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes. Molecules. 2007; 12(8):2029-2037.

Chicago/Turabian Style

Xu, Lan-Lan; Zou, Kun; Wang, Jun-Zhi; Wu, Jun; Zhou, Yuan; Dan, Fei-Jun; Yang, Jing. 2007. "New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes." Molecules 12, no. 8: 2029-2037.

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