New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

doi:10.3390/12082029

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Molecules 2007, 12(8), 2029-2037; doi:10.3390/12082029

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New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

Lan-Lan Xu¹, Kun Zou^1,* , Jun-Zhi Wang¹, Jun Wu², Yuan Zhou¹, Fei-Jun Dan¹ and Jing Yang¹

¹ Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, P.R. China ² Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China

* Author to whom correspondence should be addressed.

Received: 8 June 2007; in revised form: 11 July 2007 / Accepted: 12 July 2007 / Published: 23 August 2007

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Abstract: Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,7α,22ξ,26- octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.

Keywords: Furostanol Saponins; Tupistra chinensis Bak.; Liliaceae; Convallarieae; NO

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MDPI and ACS Style

Xu, L.-L.; Zou, K.; Wang, J.-Z.; Wu, J.; Zhou, Y.; Dan, F.-J.; Yang, J. New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes. Molecules 2007, 12, 2029-2037.

AMA Style

Xu L-L, Zou K, Wang J-Z, Wu J, Zhou Y, Dan F-J, Yang J. New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes. Molecules. 2007; 12(8):2029-2037.

Chicago/Turabian Style

Xu, Lan-Lan; Zou, Kun; Wang, Jun-Zhi; Wu, Jun; Zhou, Yuan; Dan, Fei-Jun; Yang, Jing. 2007. "New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes." Molecules 12, no. 8: 2029-2037.

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