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Molecules 2007, 12(8), 2029-2037; doi:10.3390/12082029
Article

New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

1, 1,* , 1, 2
,
1
,
1
 and
1
1 Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, P.R. China 2 Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China
* Author to whom correspondence should be addressed.
Received: 8 June 2007 / Revised: 11 July 2007 / Accepted: 12 July 2007 / Published: 23 August 2007
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Abstract

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-δ25(27)-en-1β,2β,3β,4β,5β,7α,22ξ,26- octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-δ25(27)-en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.
Keywords: Furostanol Saponins; Tupistra chinensis Bak.; Liliaceae; Convallarieae; NO Furostanol Saponins; Tupistra chinensis Bak.; Liliaceae; Convallarieae; NO
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xu, L.-L.; Zou, K.; Wang, J.-Z.; Wu, J.; Zhou, Y.; Dan, F.-J.; Yang, J. New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes. Molecules 2007, 12, 2029-2037.

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