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Molecules 2007, 12(8), 1900-1909; doi:10.3390/12081900
Article

Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds

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Received: 2 August 2007; in revised form: 14 August 2007 / Accepted: 14 August 2007 / Published: 17 August 2007
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Abstract: A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.
Keywords: 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity. 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Haider, N.; Kabicher, T.; Käferböck, J.; Plenk, A. Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds. Molecules 2007, 12, 1900-1909.

AMA Style

Haider N, Kabicher T, Käferböck J, Plenk A. Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds. Molecules. 2007; 12(8):1900-1909.

Chicago/Turabian Style

Haider, Norbert; Kabicher, Tamara; Käferböck, Johann; Plenk, Angelika. 2007. "Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds." Molecules 12, no. 8: 1900-1909.



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