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Molecules 2007, 12(8), 1900-1909; doi:10.3390/12081900
Article

Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds

* , ,  and
Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 2 August 2007 / Revised: 14 August 2007 / Accepted: 14 August 2007 / Published: 17 August 2007
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Abstract

A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.
Keywords: 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity. 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Haider, N.; Kabicher, T.; Käferböck, J.; Plenk, A. Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds. Molecules 2007, 12, 1900-1909.

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