Molecules 2007, 12(8), 1900-1909; doi:10.3390/12081900
Article

Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds

Norbert Haider* email, Tamara Kabicher, Johann Käferböck and Angelika Plenk
Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 2 August 2007; in revised form: 14 August 2007 / Accepted: 14 August 2007 / Published: 17 August 2007
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Abstract: A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.
Keywords: 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity.

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MDPI and ACS Style

Haider, N.; Kabicher, T.; Käferböck, J.; Plenk, A. Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds. Molecules 2007, 12, 1900-1909.

AMA Style

Haider N, Kabicher T, Käferböck J, Plenk A. Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds. Molecules. 2007; 12(8):1900-1909.

Chicago/Turabian Style

Haider, Norbert; Kabicher, Tamara; Käferböck, Johann; Plenk, Angelika. 2007. "Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds." Molecules 12, no. 8: 1900-1909.

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