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Molecules 2007, 12(8), 1805-1816; doi:10.3390/12081805
Article

A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

1, 1,* , 2, 3, 1, 4, 4 and 5
1 Education Faculty, Kafkas University, 36100 Kars, Turkey 2 Department of Chemistry, Rize University, Rize, Turkey 3 Fatih Education Faculty, Karadeniz Technical University, 61335 Trabzon, Turkey 4 Gaziosmanpasa University, Dept. of Chemistry, Tokat, Turkey 5 Department of Chemistry, Karadeniz Technical University, 61100 Trabzon, Turkey
* Author to whom correspondence should be addressed.
Received: 28 May 2007 / Revised: 2 August 2007 / Accepted: 2 August 2007 / Published: 13 August 2007
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Abstract

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)- 4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.
Keywords: 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant. 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Alkan, M.; Yüksek, H.; İslamoğlu, F.; Bahçeci, S.; Calapoğlu, M.; Elmastaş, M.; Akşit, H.; Özdemir, M. A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones. Molecules 2007, 12, 1805-1816.

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