Next Article in Journal
Synthesis of Novel Benzimidazolyl-substituted Acrylonitriles and Amidino-substituted Benzimidazo[1,2-a]Quinolines
Previous Article in Journal
Synthesis of Some New Anils: Part 1. Reaction of 2-Hydroxy-benzaldehyde and 2-Hydroxynaphthaldehyde with 2-Aminopyridene and 2-Aminopyrazine
Article Menu

Export Article

Open AccessArticle
Molecules 2007, 12(8), 1805-1816; doi:10.3390/12081805

A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

1
Education Faculty, Kafkas University, 36100 Kars, Turkey
2
Department of Chemistry, Rize University, Rize, Turkey
3
Fatih Education Faculty, Karadeniz Technical University, 61335 Trabzon, Turkey
4
Gaziosmanpasa University, Dept. of Chemistry, Tokat, Turkey
5
Department of Chemistry, Karadeniz Technical University, 61100 Trabzon, Turkey
*
Author to whom correspondence should be addressed.
Received: 28 May 2007 / Revised: 2 August 2007 / Accepted: 2 August 2007 / Published: 13 August 2007
View Full-Text   |   Download PDF [149 KB, uploaded 18 June 2014]   |  

Abstract

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)- 4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities. View Full-Text
Keywords: 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant. 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Alkan, M.; Yüksek, H.; İslamoğlu, F.; Bahçeci, S.; Calapoğlu, M.; Elmastaş, M.; Akşit, H.; Özdemir, M. A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones. Molecules 2007, 12, 1805-1816.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top