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Molecules 2007, 12(8), 1606-1613; doi:10.3390/12081606

Antibacterial Thymol Derivatives Isolated from Centipeda minima

1, 3, 2, 4, 3, 1 and 1,*
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China 2 College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P. R. China 3 Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031, P. R. China 4 College of Bioengineering, Southwest Jiaotong University, Chengdu 610031, P. R. China
* Author to whom correspondence should be addressed.
Received: 19 June 2007 / Revised: 3 July 2007 / Accepted: 3 July 2007 / Published: 27 July 2007
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Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-β-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
Keywords: Centipeda minima; Compositae; thymol derivatives; antibacterial activity Centipeda minima; Compositae; thymol derivatives; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liang, H.; Bao, F.; Dong, X.; Tan, R.; Zhang, C.; Lu, Q.; Cheng, Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules 2007, 12, 1606-1613.

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