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Molecules 2007, 12(8), 1606-1613; doi:10.3390/12081606
Article

Antibacterial Thymol Derivatives Isolated from Centipeda minima

1, 3, 2, 4, 3, 1 and 1,*
Received: 19 June 2007 / Revised: 3 July 2007 / Accepted: 3 July 2007 / Published: 27 July 2007
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Abstract

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-β-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
Keywords: Centipeda minima; Compositae; thymol derivatives; antibacterial activity Centipeda minima; Compositae; thymol derivatives; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liang, H.; Bao, F.; Dong, X.; Tan, R.; Zhang, C.; Lu, Q.; Cheng, Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules 2007, 12, 1606-1613.

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