Abstract: Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-β-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
Keywords: Centipeda minima; Compositae; thymol derivatives; antibacterial activity
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Liang, H.; Bao, F.; Dong, X.; Tan, R.; Zhang, C.; Lu, Q.; Cheng, Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules 2007, 12, 1606-1613.
Liang H, Bao F, Dong X, Tan R, Zhang C, Lu Q, Cheng Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules. 2007; 12(8):1606-1613.
Liang, Hengxing; Bao, Fukai; Dong, Xiaoping; Tan, Rui; Zhang, Caijun; Lu, Qing; Cheng, Yongxian. 2007. "Antibacterial Thymol Derivatives Isolated from Centipeda minima." Molecules 12, no. 8: 1606-1613.