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Antibacterial Thymol Derivatives Isolated from Centipeda minima
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P. R. China
Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031, P. R. China
College of Bioengineering, Southwest Jiaotong University, Chengdu 610031, P. R. China
* Author to whom correspondence should be addressed.
Received: 19 June 2007; in revised form: 3 July 2007 / Accepted: 3 July 2007 / Published: 27 July 2007
Abstract: Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-β-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.
Keywords: Centipeda minima; Compositae; thymol derivatives; antibacterial activity
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MDPI and ACS Style
Liang, H.; Bao, F.; Dong, X.; Tan, R.; Zhang, C.; Lu, Q.; Cheng, Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules 2007, 12, 1606-1613.
Liang H, Bao F, Dong X, Tan R, Zhang C, Lu Q, Cheng Y. Antibacterial Thymol Derivatives Isolated from Centipeda minima. Molecules. 2007; 12(8):1606-1613.
Liang, Hengxing; Bao, Fukai; Dong, Xiaoping; Tan, Rui; Zhang, Caijun; Lu, Qing; Cheng, Yongxian. 2007. "Antibacterial Thymol Derivatives Isolated from Centipeda minima." Molecules 12, no. 8: 1606-1613.