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β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta
University of Athens, Department of Pharmacy, Division of Pharmacognosy and Chemistry of Natural Products, Panepistimioupoli Zographou, Athens, 157 71, Greece
Department of Food Quality and Chemistry of Naturals Products, Mediterranean Agronomic Institute of Chania, Alsyllion Agrokepiou, Chania, 73100, Crete, Greece
* Author to whom correspondence should be addressed.
Received: 27 March 2007; in revised form: 7 May 2007 / Accepted: 11 May 2007 / Published: 12 May 2007
Abstract: Four new β-orcinol metabolites, hypotrachynic acid (1), deoxystictic acid (2), cryptostictinolide (3) and 8 ́-methylconstictic acid (4) along with the metabolites 8 ́-methylstictic acid (5), 8 ́-methylmenegazziaic acid (6), stictic acid (7), 8 ́-ethylstictic acid (8) and atranorin (9), that have been previously described, were isolated for the first time from the tissue extracts of the lichen Hypotrachyna revoluta (Flörke) Hale. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analyses. Radical scavenging activity (RSA) of the metabolites isolated in adequate amounts, was evaluated using luminol chemiluminescence and comparison with Trolox®.
Keywords: Hypotrachyna revoluta; Hypotrachynic acid; Deoxystictic acid; Cryptostictinolide; 8΄-Methylconstictic acid; Radical scavenging activity
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Papadopoulou, P.; Tzakou, O.; Vagias, C.; Kefalas, P.; Roussis, V. β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta. Molecules 2007, 12, 997-1005.
Papadopoulou P, Tzakou O, Vagias C, Kefalas P, Roussis V. β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta. Molecules. 2007; 12(5):997-1005.
Papadopoulou, Panagiota; Tzakou, Olga; Vagias, Constantinos; Kefalas, Panagiotis; Roussis, Vassilios. 2007. "β-Orcinol Metabolites from the Lichen Hypotrachyna revoluta." Molecules 12, no. 5: 997-1005.