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Molecules 2007, 12(5), 1183-1190; https://doi.org/10.3390/12051183

Facile Synthesis of Optically Active Imidazole Derivatives

Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs. legii 565, Pardubice, 53210, Czech Republic
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Received: 11 May 2007 / Revised: 22 May 2007 / Accepted: 23 May 2007 / Published: 30 May 2007
(This article belongs to the Special Issue Heterocycles)
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Abstract

Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine. View Full-Text
Keywords: Imidazole; condensation; optically active ligand Imidazole; condensation; optically active ligand
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Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.

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