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Molecules 2007, 12(5), 1183-1190; doi:10.3390/12051183
Article

Facile Synthesis of Optically Active Imidazole Derivatives

, ,  and *
Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs. legii 565, Pardubice, 53210, Czech Republic
* Author to whom correspondence should be addressed.
Received: 11 May 2007 / Revised: 22 May 2007 / Accepted: 23 May 2007 / Published: 30 May 2007
(This article belongs to the Special Issue Heterocycles)
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Abstract

Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine.
Keywords: Imidazole; condensation; optically active ligand Imidazole; condensation; optically active ligand
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.

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