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Facile Synthesis of Optically Active Imidazole Derivatives
Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs. legii 565, Pardubice, 53210, Czech Republic
* Author to whom correspondence should be addressed.
Received: 11 May 2007; in revised form: 22 May 2007 / Accepted: 23 May 2007 / Published: 30 May 2007
Abstract: Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine.
Keywords: Imidazole; condensation; optically active ligand
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MDPI and ACS Style
Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.
Marek A, Kulhanek J, Ludwig M, Bures F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules. 2007; 12(5):1183-1190.
Marek, Ales; Kulhanek, Jiri; Ludwig, Miroslav; Bures, Filip. 2007. "Facile Synthesis of Optically Active Imidazole Derivatives." Molecules 12, no. 5: 1183-1190.