Facile Synthesis of Optically Active Imidazole Derivatives
AbstractFive optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine. View Full-Text
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Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.
Marek A, Kulhanek J, Ludwig M, Bures F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules. 2007; 12(5):1183-1190.Chicago/Turabian Style
Marek, Ales; Kulhanek, Jiri; Ludwig, Miroslav; Bures, Filip. 2007. "Facile Synthesis of Optically Active Imidazole Derivatives." Molecules 12, no. 5: 1183-1190.