Molecules 2007, 12(5), 1183-1190; doi:10.3390/12051183

Facile Synthesis of Optically Active Imidazole Derivatives

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Received: 11 May 2007; in revised form: 22 May 2007 / Accepted: 23 May 2007 / Published: 30 May 2007
(This article belongs to the Special Issue Heterocycles)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding α-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imidazole derivatives. The derivatives thus prepared are structurally-related to histamine.
Keywords: Imidazole; condensation; optically active ligand
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MDPI and ACS Style

Marek, A.; Kulhanek, J.; Ludwig, M.; Bures, F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules 2007, 12, 1183-1190.

AMA Style

Marek A, Kulhanek J, Ludwig M, Bures F. Facile Synthesis of Optically Active Imidazole Derivatives. Molecules. 2007; 12(5):1183-1190.

Chicago/Turabian Style

Marek, Ales; Kulhanek, Jiri; Ludwig, Miroslav; Bures, Filip. 2007. "Facile Synthesis of Optically Active Imidazole Derivatives." Molecules 12, no. 5: 1183-1190.

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