Molecules 2007, 12(5), 1170-1182; doi:10.3390/12051170
Article

Stereoselective Syntheses of Fluorescent Non-Natural Aromatic Amino Acids Based on Asymmetric Michael Additions

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Received: 10 May 2007; in revised form: 24 May 2007 / Accepted: 25 May 2007 / Published: 26 May 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four fluorescent non-natural aromatic amino acids have been synthesized based on a key stereoselective Michael addition reaction. S-1-Phenylethylamine was employed as both the source of amine and the stereoselectivity controller. The overall yields were moderate (30-50%). Fluorescent properties of some of the fluorophores were also investigated. It was found that compounds with a dimethylamino group bonded to the aromatic ring display intramolecular charge transfer fluorescence.
Keywords: Aladan; fluorescent non-natural amino acids; asymmetric Michael addition; stereoselective synthesis
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MDPI and ACS Style

Chen, H.; Zhong, X.; Wei, J. Stereoselective Syntheses of Fluorescent Non-Natural Aromatic Amino Acids Based on Asymmetric Michael Additions. Molecules 2007, 12, 1170-1182.

AMA Style

Chen H, Zhong X, Wei J. Stereoselective Syntheses of Fluorescent Non-Natural Aromatic Amino Acids Based on Asymmetric Michael Additions. Molecules. 2007; 12(5):1170-1182.

Chicago/Turabian Style

Chen, Heru; Zhong, Xianbin; Wei, Jin. 2007. "Stereoselective Syntheses of Fluorescent Non-Natural Aromatic Amino Acids Based on Asymmetric Michael Additions." Molecules 12, no. 5: 1170-1182.

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