Molecules 2007, 12(5), 1153-1162; doi:10.3390/12051153
Article

Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

Ana Paula Pereira 1 , Isabel CFR Ferreira 1 , Filipa Marcelino 1 , Patricia Valentão 2 , Paula B Andrade 2 , Rosa Seabra 2 , Leticia Estevinho 1 , Albino Bento 1  and José Alberto Pereira 1,* email
1 CIMO / Escola Superior Agrária, Instituto Politécnico de Bragança, Campus Sta Apolónia, Apt. 1172, 5301-855 Bragança, Portugal 2 REQUIMTE / Serviço de Farmacognosia, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
* Author to whom correspondence should be addressed.
Received: 23 February 2007; in revised form: 24 May 2007 / Accepted: 24 May 2007 / Published: 26 May 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract: We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely Gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4’-O-glucoside. At low concentrations olive leafs extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particulalry as a source of phenolic compounds.
Keywords: Olive leaves; Phenolic compounds; Antibacterial activity; Antifungal activity

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Cite This Article

MDPI and ACS Style

Pereira, A.P.; Ferreira, I.C.; Marcelino, F.; Valentão, P.; Andrade, P.B.; Seabra, R.; Estevinho, L.; Bento, A.; Pereira, J.A. Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves. Molecules 2007, 12, 1153-1162.

AMA Style

Pereira AP, Ferreira IC, Marcelino F, Valentão P, Andrade PB, Seabra R, Estevinho L, Bento A, Pereira JA. Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves. Molecules. 2007; 12(5):1153-1162.

Chicago/Turabian Style

Pereira, Ana P.; Ferreira, Isabel C.; Marcelino, Filipa; Valentão, Patricia; Andrade, Paula B.; Seabra, Rosa; Estevinho, Leticia; Bento, Albino; Pereira, José A. 2007. "Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves." Molecules 12, no. 5: 1153-1162.

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