Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines

doi:10.3390/12051136

This article is

freely available
re-usable

Molecules 2007, 12(5), 1136-1146; doi:10.3390/12051136

Article

Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines

Xiang-Lin Zhao, Yan-Fang Zhao, Shu-Chun Guo, Hai-Sheng Song, Ding Wang and Ping Gong*

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China

* Author to whom correspondence should be addressed.

Received: 8 May 2007; in revised form: 24 May 2007 / Accepted: 24 May 2007 / Published: 25 May 2007

Download PDF Full-Text [106 KB, uploaded 2 October 2008 11:53 CEST]

Abstract: A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, ¹H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC₅₀ values of 12.3 μM and 6.1 μM against Bel-7402 and HT-1080 cell lines respectively.

Keywords: [1; 2; 4]Triazolo[1; 5-a]pyrimidines; Synthesis; antitumor activities

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Zhao, X.-L.; Zhao, Y.-F.; Guo, S.-C.; Song, H.-S.; Wang, D.; Gong, P. Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines. Molecules 2007, 12, 1136-1146.

AMA Style

Zhao X.-L., Zhao Y.-F., Guo S.-C., Song H.-S., Wang D., Gong P. Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines. Molecules. 2007; 12(5):1136-1146.

Chicago/Turabian Style

Zhao, Xiang-Lin; Zhao, Yan-Fang; Guo, Shu-Chun; Song, Hai-Sheng; Wang, Ding; Gong, Ping. 2007. "Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines." Molecules 12, no. 5: 1136-1146.

Molecules EISSN 1420-3049 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert