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Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China
* Author to whom correspondence should be addressed.
Received: 8 May 2007; in revised form: 24 May 2007 / Accepted: 24 May 2007 / Published: 25 May 2007
Abstract: A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 μM and 6.1 μM against Bel-7402 and HT-1080 cell lines respectively.
Keywords: [1; 2; 4]Triazolo[1; 5-a]pyrimidines; Synthesis; antitumor activities
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MDPI and ACS Style
Zhao, X.-L.; Zhao, Y.-F.; Guo, S.-C.; Song, H.-S.; Wang, D.; Gong, P. Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines. Molecules 2007, 12, 1136-1146.
Zhao X-L, Zhao Y-F, Guo S-C, Song H-S, Wang D, Gong P. Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines. Molecules. 2007; 12(5):1136-1146.
Zhao, Xiang-Lin; Zhao, Yan-Fang; Guo, Shu-Chun; Song, Hai-Sheng; Wang, Ding; Gong, Ping. 2007. "Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines." Molecules 12, no. 5: 1136-1146.