Molecules 2007, 12(3), 641-653; doi:10.3390/12030641
Article

Novel Aflatoxin Derivatives and Protein Conjugates

Christian Cervino 1,* email, Dietmar Knopp 1 email, Michael G Weller 2 email and Reinhard Niessner 1
1 Institute of Hydrochemistry, Chair for Analytical Chemistry, Technische Universität München, Marchioninistrasse 17, 81377 München, Germany; 2 Federal Institute for Materials Research and Testing (BAM), Division I.5 (Bioanalytics), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany
* Author to whom correspondence should be addressed.
Received: 14 March 2007; in revised form: 25 March 2007 / Accepted: 26 March 2007 / Published: 27 March 2007
PDF Full-text Download PDF Full-Text [152 KB, uploaded 2 October 2008 11:53 CEST]
Abstract: Aflatoxins, a group of structurally related mycotoxins, are well known for their toxic and carcinogenic effects in humans and animals. Aflatoxin derivatives and protein conjugates are needed for diverse analytical applications. This work describes a reliable and fast synthesis of novel aflatoxin derivatives, purification by preparative HPLC and characterisation by ESI-MS and one- and two-dimensional NMR. Novel aflatoxin bovine serum albumin conjugates were prepared and characterised by UV absorption and MALDI-MS. These aflatoxin protein conjugates are potentially interesting as immunogens for the generation of aflatoxin selective antibodies with novel specificities.
Keywords: Aflatoxin; mycotoxin; hapten; protein conjugation; immunogen; antigen; antibody

Supplementary Files

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Cervino, C.; Knopp, D.; Weller, M.G.; Niessner, R. Novel Aflatoxin Derivatives and Protein Conjugates. Molecules 2007, 12, 641-653.

AMA Style

Cervino C, Knopp D, Weller MG, Niessner R. Novel Aflatoxin Derivatives and Protein Conjugates. Molecules. 2007; 12(3):641-653.

Chicago/Turabian Style

Cervino, Christian; Knopp, Dietmar; Weller, Michael G.; Niessner, Reinhard. 2007. "Novel Aflatoxin Derivatives and Protein Conjugates." Molecules 12, no. 3: 641-653.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert