Molecules 2007, 12(3), 439-454; doi:10.3390/12030439
Article

Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

1 Faculté des Sciences, Département de Chimie, Université d’Es-sénia, Oran, B.P 1524, Algeria 2 Groupe d'Ingénierie Chimique et Molécules pour le Vivant 3(ICMV3)-UMR 6226, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France
* Author to whom correspondence should be addressed.
Received: 27 January 2007; in revised form: 17 February 2007 / Accepted: 7 March 2007 / Published: 12 March 2007
PDF Full-text Download PDF Full-Text [159 KB, uploaded 20 June 2008 16:50 CEST]
Abstract: We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
Keywords: Medium-sized ring lactams; imine alkylation; Schiff bases; microwave irradiation

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Zradni, F.-Z.; Hamelin, J.; Derdour, A. Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation. Molecules 2007, 12, 439-454.

AMA Style

Zradni F-Z, Hamelin J, Derdour A. Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation. Molecules. 2007; 12(3):439-454.

Chicago/Turabian Style

Zradni, Fatima-Zohra; Hamelin, Jack; Derdour, Aicha. 2007. "Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation." Molecules 12, no. 3: 439-454.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert