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Molecules 2007, 12(3), 439-454; doi:10.3390/12030439
Article

Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

1,* , 2
 and
1
1 Faculté des Sciences, Département de Chimie, Université d’Es-sénia, Oran, B.P 1524, Algeria 2 Groupe d'Ingénierie Chimique et Molécules pour le Vivant 3(ICMV3)-UMR 6226, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France
* Author to whom correspondence should be addressed.
Received: 27 January 2007 / Revised: 17 February 2007 / Accepted: 7 March 2007 / Published: 12 March 2007
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Abstract

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
Keywords: Medium-sized ring lactams; imine alkylation; Schiff bases; microwave irradiation Medium-sized ring lactams; imine alkylation; Schiff bases; microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zradni, F.-Z.; Hamelin, J.; Derdour, A. Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation. Molecules 2007, 12, 439-454.

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