Next Article in Journal
Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides
Previous Article in Journal
N,N'-Ethylene-bis(benzoylacetoniminato) Copper (II), Cu(C22H22N2O2), a New Reagent for Aromatization of Hantzsch 1,4-Dihydropyridines
Molecules 2007, 12(3), 439-454; doi:10.3390/12030439
Article

Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

1,* , 2
 and 1
Received: 27 January 2007; in revised form: 17 February 2007 / Accepted: 7 March 2007 / Published: 12 March 2007
Download PDF [159 KB, uploaded 18 June 2014]
Abstract: We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.
Keywords: Medium-sized ring lactams; imine alkylation; Schiff bases; microwave irradiation Medium-sized ring lactams; imine alkylation; Schiff bases; microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Zradni, F.-Z.; Hamelin, J.; Derdour, A. Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation. Molecules 2007, 12, 439-454.

AMA Style

Zradni F-Z, Hamelin J, Derdour A. Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation. Molecules. 2007; 12(3):439-454.

Chicago/Turabian Style

Zradni, Fatima-Zohra; Hamelin, Jack; Derdour, Aicha. 2007. "Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation." Molecules 12, no. 3: 439-454.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert