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Molecules 2007, 12(2), 245-254; doi:10.3390/12020245
Article

Synthesis, Characterization and AntibacterialActivity of Azomethine Derivatives Derived from 2-Formylphenoxyacetic Acid

1
,
1,* , 2
,
1
 and
3
1 Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan 2 Department of Chemistry, Forman Christian College (A Chartered University) Lahore-54600, Pakistan 3 Department of Chemistry, Loughborough University, Loughborough, LE 11 3TU, UK
* Author to whom correspondence should be addressed.
Received: 10 February 2007 / Revised: 20 February 2007 / Accepted: 21 February 2007 / Published: 22 February 2007
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Abstract

A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b, 2e, 2g and 2h exhibited good antibacterial activity, almost equal to that of Ciprofloxacin used as standard.
Keywords: 2-Formylphenoxyacetic acid; picoline;N-phenylhydrazine; p-toluidine;o bromobenzylamine;2; 3-dichloroaniline; p-aminoacetanilide; imidazole; thiazole; antibacterial activity 2-Formylphenoxyacetic acid; picoline; N-phenylhydrazine; p-toluidine; o bromobenzylamine; 2; 3-dichloroaniline; p-aminoacetanilide; imidazole; thiazole; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Iqbal, A.; Siddiqui, H.L.; Ashraf, C.M.; Ahmad, M.; Weaver, G.W. Synthesis, Characterization and AntibacterialActivity of Azomethine Derivatives Derived from 2-Formylphenoxyacetic Acid. Molecules 2007, 12, 245-254.

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