Molecules 2007, 12(2), 237-244; doi:10.3390/12020237
Article

Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones

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Received: 9 January 2007; in revised form: 20 February 2007 / Accepted: 20 February 2007 / Published: 21 February 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The asymmetric rhodium-catalysed 1,4-addition of alkenylzirconium reagents to 2-cyclohexenone can be useful in the synthesis of 3-alkenyl-2-methylcyclohexanones, provided that formaldehyde is used in trapping the intermediate zirconium enolates. In this manner a four-step sequence leading to the two epimeric 3-hexenyl-2-methylcyclohexanones in enantiomeric form was developed.
Keywords: Enantioselective 1; 4-addition;zirconium O-enolate trapping;2-cyclo-hexenone.
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MDPI and ACS Style

Vrielynck, F.A.; De Clercq, P.J. Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones. Molecules 2007, 12, 237-244.

AMA Style

Vrielynck FA, De Clercq PJ. Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones. Molecules. 2007; 12(2):237-244.

Chicago/Turabian Style

Vrielynck, Freek A.; De Clercq, Pierre J. 2007. "Asymmetric Synthesis of the Epimeric (3S)-3-((E)-Hex-1-enyl)-2-methylcyclohexanones." Molecules 12, no. 2: 237-244.

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