Molecules 2007, 12(2), 218-230; doi:10.3390/12020218
Article

Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Nisachon Khunnawutmanotham 1 email, Nitirat Chimnoi 1 email, Patchareenart Saparpakorn 2 email, Pornpan Pungpo 3 email, Suda Louisirirotchanakul 4 email, Supa Hannongbua 2 email and Supanna Techasakul 1,* email
1 Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand
2 Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand
3 Department of Chemistry, Faculty of Science, Ubonratchathani University, Ubonratchathani 34190, Thailand
4 Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
* Author to whom correspondence should be addressed.
Received: 22 December 2006; in revised form: 18 February 2007 / Accepted: 19 February 2007 / Published: 20 February 2007
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Abstract: Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
Keywords: Dipyridodiazepinone; HIV-1 RT; antiviral activity

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MDPI and ACS Style

Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Pungpo, P.; Louisirirotchanakul, S.; Hannongbua, S.; Techasakul, S. Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules 2007, 12, 218-230.

AMA Style

Khunnawutmanotham N., Chimnoi N., Saparpakorn P., Pungpo P., Louisirirotchanakul S., Hannongbua S., Techasakul S. Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules. 2007; 12(2):218-230.

Chicago/Turabian Style

Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Saparpakorn, Patchareenart; Pungpo, Pornpan; Louisirirotchanakul, Suda; Hannongbua, Supa; Techasakul, Supanna. 2007. "Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase." Molecules 12, no. 2: 218-230.

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