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Molecules 2007, 12(2), 218-230; doi:10.3390/12020218
Article

Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

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 and
1,*
1 Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand 2 Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand 3 Department of Chemistry, Faculty of Science, Ubonratchathani University, Ubonratchathani 34190, Thailand 4 Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
* Author to whom correspondence should be addressed.
Received: 22 December 2006 / Revised: 18 February 2007 / Accepted: 19 February 2007 / Published: 20 February 2007
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Abstract

Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
Keywords: Dipyridodiazepinone; HIV-1 RT; antiviral activity Dipyridodiazepinone; HIV-1 RT; antiviral activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Pungpo, P.; Louisirirotchanakul, S.; Hannongbua, S.; Techasakul, S. Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules 2007, 12, 218-230.

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