Molecules 2007, 12(2), 218-230; doi:10.3390/12020218
Article

Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

1email, 1email, 2email, 3email, 4email, 2email and 1,* email
Received: 22 December 2006; in revised form: 18 February 2007 / Accepted: 19 February 2007 / Published: 20 February 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Based on the molecular modeling analysis against Y181CHIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactamnitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficientroute. Some of them were evaluated for their antiviral activity against HIV-1RT subtype E and were found to exhibit virustatic activity comparable to some clinically usedtherapeutic agents.
Keywords: Dipyridodiazepinone; HIV-1 RT; antiviral activity
PDF Full-text Download PDF Full-Text [127 KB, uploaded 18 June 2014 19:27 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Khunnawutmanotham, N.; Chimnoi, N.; Saparpakorn, P.; Pungpo, P.; Louisirirotchanakul, S.; Hannongbua, S.; Techasakul, S. Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules 2007, 12, 218-230.

AMA Style

Khunnawutmanotham N, Chimnoi N, Saparpakorn P, Pungpo P, Louisirirotchanakul S, Hannongbua S, Techasakul S. Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase. Molecules. 2007; 12(2):218-230.

Chicago/Turabian Style

Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Saparpakorn, Patchareenart; Pungpo, Pornpan; Louisirirotchanakul, Suda; Hannongbua, Supa; Techasakul, Supanna. 2007. "Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase." Molecules 12, no. 2: 218-230.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert