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Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan
Medicinal Botanic Centre, PCSIR Labs. Complex Peshawar, Peshawar, N.W.F.P, Pakistan
Pharmaceutical Research Centre, PCSIR Labs. Complex, Karachi-75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 6 January 2007; in revised form: 21 January 2007 / Accepted: 22 January 2007 / Published: 6 February 2007
Abstract: Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.
Keywords: Isatis costata; Brassicaseae; oxindole alkaloids; structure elucidation; antifungal activity
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Fatima, I.; Ahmad, I.; Anis, I.; Malik, A.; Afza, N. Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata. Molecules 2007, 12, 155-162.
Fatima I, Ahmad I, Anis I, Malik A, Afza N. Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata. Molecules. 2007; 12(2):155-162.
Fatima, Itrat; Ahmad, Ijaz; Anis, Itrat; Malik, Abdul; Afza, Nighat. 2007. "Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata." Molecules 12, no. 2: 155-162.