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• Fatima, I
• Ahmad, I
• Anis, I
• Malik, A
• Afza, N
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• Fatima, I
• Ahmad, I
• Anis, I
• Malik, A
• Afza, N
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• Ahmad, I
• Anis, I
• Malik, A
• Afza, N

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Molecules 2007, 12(2), 155-162; doi:10.3390/12020155

Article

Isatinones A and B, New Antifungal Oxindole Alkaloids from Isatis costata

Itrat Fatima ¹ , Ijaz Ahmad ² , Itrat Anis ¹ , Abdul Malik ^1,*  and Nighat Afza ³

¹ International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan ² Medicinal Botanic Centre, PCSIR Labs. Complex Peshawar, Peshawar, N.W.F.P, Pakistan ³ Pharmaceutical Research Centre, PCSIR Labs. Complex, Karachi-75270, Pakistan

* Author to whom correspondence should be addressed.

Received: 6 January 2007; in revised form: 21 January 2007 / Accepted: 22 January 2007 / Published: 6 February 2007

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Abstract: Two new oxindole alkaloids isatinone A (1) and B (2) have been isolated from Isatis costata, along with the known trisindoline. Their structures have been assigned on the basis of spectroscopic techniques and chemical studies. Both new compounds showed significant antifungal activity.

Keywords: Isatis costata; Brassicaseae; oxindole alkaloids; structure elucidation; antifungal activity

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