Molecules 2007, 12(10), 2348-2363; doi:10.3390/12102348
Article

Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid

Muhammad Sheeraz Ahmad 1 email, Mukhtiar Hussain 2 , Muhammad Hanif 2 , Saqib Ali 2  and Bushra Mirza 1,* email
1 Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad Pakistan 2 Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
* Author to whom correspondence should be addressed.
Received: 17 July 2007; in revised form: 9 August 2007 / Accepted: 10 August 2007 / Published: 25 October 2007
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Abstract: A series of mono-, di- and triorganotin compounds with general formulae [RSnL2Cl], R = Bu (compound 3), [R2SnL2], where R = Me, Et, Bu, Oct (compounds 1, 2, 4 and 6) and [R3SnL], where R = Bu, Cy and Ph (compounds 5, 7 and 8) and where L = 3,4-methylenedioxy-6-nitrophenylpropenoic acid have been prepared and characterized by elemental analysis, multinuclear (1H-, 13C- and 119Sn-) NMR and mass spectrometry. The ligand and its respective organotin complexes were screened for cytotoxicity using the brine shrimp lethality assay and for antitumor activity using the crown gall tumor inhibition (potato disc) assay. The bioassay results support the conclusion that the biological activities of these synthetic compounds are in the following order: [RSnL2Cl] < [R2SnL2] < [R3SnL].
Keywords: Antitumor; cytotoxicity; mass spectrometry; multinuclear NMR; organotin

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MDPI and ACS Style

Ahmad, M.S.; Hussain, M.; Hanif, M.; Ali, S.; Mirza, B. Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid. Molecules 2007, 12, 2348-2363.

AMA Style

Ahmad MS, Hussain M, Hanif M, Ali S, Mirza B. Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid. Molecules. 2007; 12(10):2348-2363.

Chicago/Turabian Style

Ahmad, Muhammad S.; Hussain, Mukhtiar; Hanif, Muhammad; Ali, Saqib; Mirza, Bushra. 2007. "Synthesis, Chemical Characterization and Biological Screening for Cytotoxicity and Antitumor Activity of Organotin (IV) Derivatives of 3,4-Methylenedioxy 6-nitrophenylpropenoic Acid." Molecules 12, no. 10: 2348-2363.

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