Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

doi:10.3390/12010103

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Molecules 2007, 12(1), 103-113; doi:10.3390/12010103

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Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety

Otilia Pintilie ¹ , Lenuta Profire ²^,* , Valeriu Sunel ¹ , Marcel Popa ³ and Aurel Pui ³

¹ Department of Organic Chemistry and Biochemistry and 4 Department of Inorganic Chemistry; Faculty of Chemistry, “Al. I. Cuza” University, Bd. Carol I, no. 11, 700506 Iasi, Romania ² Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Gr. T. Popa” Medicine and Pharmacy University, Universitatii Street, no. 16, 700115 Iasi, Romania ³ Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering, “Gh. Asachi” Technical University, Bd. Mangeron, no. 71A, 700050, Iasi, Romania

* Author to whom correspondence should be addressed.

Received: 4 December 2006; in revised form: 25 January 2007 / Accepted: 26 January 2007 / Published: 29 January 2007

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Abstract: New 1,3,4-thiadiazole, 5a-e, and 1,2,4-triazolecompounds 6a-c, containing a D,L-methionine moiety were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 4a-e in acid and alkaline media, respectively. The potential antimicrobial effects of the synthesized compounds were investigated using the Staphylococcus aureus ATCC 25923, Bacillus antracis ATCC 8705, Bacillus cereus ATCC 10987, Sarcina lutea ATCC 9341 and Escherichia coli ATCC 25922 strains. The newly synthesized compounds exhibited promising activities against Bacillus antracis and Bacillus cereus.

Keywords: 1;3;4-Thiadiazole; 1;2;4-triazole; thiosemicarbazide; D;L-methionine; antimicrobial activity

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MDPI and ACS Style

Pintilie, O.; Profire, L.; Sunel, V.; Popa, M.; Pui, A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules 2007, 12, 103-113.

AMA Style

Pintilie O., Profire L., Sunel V., Popa M., Pui A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety. Molecules. 2007; 12(1):103-113.

Chicago/Turabian Style

Pintilie, Otilia; Profire, Lenuta; Sunel, Valeriu; Popa, Marcel; Pui, Aurel. 2007. "Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Having a D,L-Methionine Moiety." Molecules 12, no. 1: 103-113.

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