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Salicylanilide Acetates: Synthesis and Antibacterial Evaluation
Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
Faculty of Medicine and University Hospital, Charles University in Prague, Sokolska 581, 500 05 Hradec Kralove , Czech Republic
Zentiva a.s., U Kabelovny 130, 102 37 Prague, Czech Republic
National Reference Laboratory for Mycobacterium kansasii, Regional Institute of Hygiene, 728 92 Ostrava, Czech Republic
* Author to whom correspondence should be addressed.
Received: 27 October 2008; in revised form: 3 December 2008 / Accepted: 4 December 2008 / Published: 1 January 2008
Abstract: A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment.
Keywords: Salicylanilide acetates; in vitro antifungal activity; in vitro antimycobacterial activity; lipophilicity determination; cytotoxicity; structure-activity relationships
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Vinsova, J.; Imramovsky, A.; Buchta, V.; Ceckova, M.; Dolezal, M.; Staud, F.; Jampilek, J.; Kaustova, J. Salicylanilide Acetates: Synthesis and Antibacterial Evaluation. Molecules 2007, 12, 1-12.
Vinsova J, Imramovsky A, Buchta V, Ceckova M, Dolezal M, Staud F, Jampilek J, Kaustova J. Salicylanilide Acetates: Synthesis and Antibacterial Evaluation. Molecules. 2007; 12(1):1-12.
Vinsova, Jarmila; Imramovsky, Ales; Buchta, Vladimir; Ceckova, Martina; Dolezal, Martin; Staud, Frantisek; Jampilek, Josef; Kaustova, Jarmila. 2007. "Salicylanilide Acetates: Synthesis and Antibacterial Evaluation." Molecules 12, no. 1: 1-12.