Molecules 2006, 11(9), 666-676; doi:10.3390/11090666
Article

Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

Yingshu Xu 1 email, Kai Yan 1 , Baoan Song 1,* email, Gangfang Xu 1 email, Song Yang 1 email, Wei Xue 1 , Deyu Hu 1 email, Ping Lu 1 email, Guiping Ouyang 1 email, Linhong Jin 1 email and Zhuo Chen 1 email
1 Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China 2 Laboratory of Medicinal Chemistry, Zunyi, Medical College, 563003, Zunyi, P. R. China
* Author to whom correspondence should be addressed.
Received: 9 August 2006; in revised form: 5 September 2006 / Accepted: 5 September 2006 / Published: 6 September 2006
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Abstract: A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity.
Keywords: Aminophosphonates; microwave irradiation; synthesis; antiviral activity

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Cite This Article

MDPI and ACS Style

Xu, Y.; Yan, K.; Song, B.; Xu, G.; Yang, S.; Xue, W.; Hu, D.; Lu, P.; Ouyang, G.; Jin, L.; Chen, Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules 2006, 11, 666-676.

AMA Style

Xu Y, Yan K, Song B, Xu G, Yang S, Xue W, Hu D, Lu P, Ouyang G, Jin L, Chen Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules. 2006; 11(9):666-676.

Chicago/Turabian Style

Xu, Yingshu; Yan, Kai; Song, Baoan; Xu, Gangfang; Yang, Song; Xue, Wei; Hu, Deyu; Lu, Ping; Ouyang, Guiping; Jin, Linhong; Chen, Zhuo. 2006. "Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties." Molecules 11, no. 9: 666-676.

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