Next Article in Journal
Cerebrosides from the Roots of Serratula chinensis
Previous Article in Journal
A Novel Triterpene from Centella asiatica
Article Menu

Export Article

Open AccessArticle
Molecules 2006, 11(9), 666-676; doi:10.3390/11090666

Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China
Laboratory of Medicinal Chemistry, Zunyi, Medical College, 563003, Zunyi, P. R. China
Author to whom correspondence should be addressed.
Received: 9 August 2006 / Revised: 5 September 2006 / Accepted: 5 September 2006 / Published: 6 September 2006
View Full-Text   |   Download PDF [178 KB, uploaded 18 June 2014]   |  


A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity. View Full-Text
Keywords: Aminophosphonates; microwave irradiation; synthesis; antiviral activity Aminophosphonates; microwave irradiation; synthesis; antiviral activity

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xu, Y.; Yan, K.; Song, B.; Xu, G.; Yang, S.; Xue, W.; Hu, D.; Lu, P.; Ouyang, G.; Jin, L.; Chen, Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules 2006, 11, 666-676.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top