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Molecules 2006, 11(9), 666-676; doi:10.3390/11090666
Article

Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

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1 Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China 2 Laboratory of Medicinal Chemistry, Zunyi, Medical College, 563003, Zunyi, P. R. China
* Author to whom correspondence should be addressed.
Received: 9 August 2006 / Revised: 5 September 2006 / Accepted: 5 September 2006 / Published: 6 September 2006
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Abstract

A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity.
Keywords: Aminophosphonates; microwave irradiation; synthesis; antiviral activity Aminophosphonates; microwave irradiation; synthesis; antiviral activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xu, Y.; Yan, K.; Song, B.; Xu, G.; Yang, S.; Xue, W.; Hu, D.; Lu, P.; Ouyang, G.; Jin, L.; Chen, Z. Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties. Molecules 2006, 11, 666-676.

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