Next Article in Journal
Molecules 2002, 7, 885-895
Previous Article in Journal
Selective Enzymatic Reduction of Aldehydes
Molecules 2006, 11(5), 371-376; doi:10.3390/11050371
Communication

First Synthesis of 3-Acetyl-2-aminothiophenes Using the Gewald Reaction

*  and
Received: 5 May 2006 / Revised: 15 May 2006 / Accepted: 16 May 2006 / Published: 16 May 2006
Download PDF [58 KB, uploaded 18 June 2014]

Abstract

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of thecorresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene – aninteresting building-block for thiophene azo dyes – are reported. Detailed spectroscopicinvestigations (1H-NMR, 13C-NMR, MS, IR) of the obtained compounds are presented.
Keywords: Gewald reaction; Thiophene synthesis; Cyclization; Condensation. Gewald reaction; Thiophene synthesis; Cyclization; Condensation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Eller, G.A.; Holzer, W. First Synthesis of 3-Acetyl-2-aminothiophenes Using the Gewald Reaction. Molecules 2006, 11, 371-376.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert