Molecules 2006, 11(5), 357-364; doi:10.3390/11050357
Article

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

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Received: 16 December 2005; in revised form: 10 February 2006 / Accepted: 12 February 2006 / Published: 10 May 2006
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate.
Keywords: Chain elongation; β-ketoesters; ethyl acetate; heterocyclic esters
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MDPI and ACS Style

Mihovilovic, M.D.; Fischer, T.C.M.; Stanetty, P. Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters. Molecules 2006, 11, 357-364.

AMA Style

Mihovilovic MD, Fischer TCM, Stanetty P. Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters. Molecules. 2006; 11(5):357-364.

Chicago/Turabian Style

Mihovilovic, Marko D.; Fischer, Thomas C.M.; Stanetty, Peter. 2006. "Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters." Molecules 11, no. 5: 357-364.

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