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Molecules 2006, 11(5), 357-364; doi:10.3390/11050357
Article

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

* ,  and
Vienna University of Technology – Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 16 December 2005 / Revised: 10 February 2006 / Accepted: 12 February 2006 / Published: 10 May 2006
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Abstract

We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate.
Keywords: Chain elongation; β-ketoesters; ethyl acetate; heterocyclic esters Chain elongation; β-ketoesters; ethyl acetate; heterocyclic esters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mihovilovic, M.D.; Fischer, T.C.M.; Stanetty, P. Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters. Molecules 2006, 11, 357-364.

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