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Molecules 2006, 11(5), 357-364; doi:10.3390/11050357

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

Vienna University of Technology – Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 December 2005 / Revised: 10 February 2006 / Accepted: 12 February 2006 / Published: 10 May 2006
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We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate. View Full-Text
Keywords: Chain elongation; β-ketoesters; ethyl acetate; heterocyclic esters Chain elongation; β-ketoesters; ethyl acetate; heterocyclic esters

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Mihovilovic, M.D.; Fischer, T.C.M.; Stanetty, P. Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters. Molecules 2006, 11, 357-364.

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