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Open AccessCommunication
Molecules 2006, 11(4), 257-262; doi:10.3390/11040257

Isolation and Biological Activity of New and Known Diterpenoids From Sideritis stricta Boiss. & Heldr.

Balikesir University, Faculty of Arts and Sciences, Department of Chemistry, 10100, Balikesir, Turkey
Received: 28 October 2005 / Revised: 20 February 2006 / Accepted: 21 February 2006 / Published: 29 March 2006
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Abstract

Nine known and one new ent-kaurene diterpenoid were isolated from the acetone extract of Sideritis stricta Boiss & Heldr. The new compound, identified as ent-1β-hydroxy-7α-acetyl-15β,16β-epoxykaurane (1) by IR, 1D and 2D NMR techniques and mass spectra, was isolated along with sideroxol (2), 7-acetyl sideroxol (3), 7-epicandicandiol (4), linearol (5), ent-7α,15β,18-trihydroxy-kaur-16-ene (6), ent-7α-acetyl,15,18-dihydroxy-kaur-16-ene (7), foliol (8), sideridiol (9) and siderol (10). The antibacterial and antifungal activities of these compounds and the whole crude acetone extract were evaluated against E. coli, S. aureus, K. pneumeonia and C. albicans.
Keywords: Kaurene; Diterpenoids; Sideritis stricta; Lamiaceae; Antibacterial Activity Kaurene; Diterpenoids; Sideritis stricta; Lamiaceae; Antibacterial Activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kilic, T. Isolation and Biological Activity of New and Known Diterpenoids From Sideritis stricta Boiss. & Heldr.. Molecules 2006, 11, 257-262.

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