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Molecules 2006, 11(2), 130-133; doi:10.3390/11020130
Article

A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution

 and
*
Department of Chemistry, Norwegian University of Science and Technology, NTNU N-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 25 January 2006 / Accepted: 24 February 2006 / Published: 25 February 2006
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Abstract

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.
Keywords: Methyl 3-fluoropyridine-4-carboxylate; methyl 3-nitropyridine-4-carboxylate; fluoride anion; nucleophilic aromatic substitution. Methyl 3-fluoropyridine-4-carboxylate; methyl 3-nitropyridine-4-carboxylate; fluoride anion; nucleophilic aromatic substitution.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tjosaas, F.; Fiksdahl, A. A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution. Molecules 2006, 11, 130-133.

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