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Molecules 2006, 11(12), 988-999; doi:10.3390/11120988
Article

Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

1
,
2
,
1, 1, 2, 1, 1, 2
 and
1,*
1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P.R. China 2 The National Center for Drug Screening, 189 Guoshoujing Road, Shanghai 201203, P.R. China
* Author to whom correspondence should be addressed.
Received: 27 November 2006 / Revised: 17 December 2006 / Accepted: 18 December 2006 / Published: 21 December 2006
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Abstract

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.
Keywords: Microwave irradiation; nucleophilic substitution; 6-substituted quinoxalines; JSP-1. Microwave irradiation; nucleophilic substitution; 6-substituted quinoxalines; JSP-1.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, L.; Qiu, B.; Li, X.; Wang, X.; Li, J.; Zhang, Y.; Liu, J.; Li, J.; Shen, J. Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution. Molecules 2006, 11, 988-999.

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