Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

doi:10.3390/11120988

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Molecules 2006, 11(12), 988-999; doi:10.3390/11120988

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Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

Li Zhang¹, Beiying Qiu², Xin Li¹, Xin Wang¹, Jingya Li², Yongliang Zhang¹, Jian Liu¹, Jia Li² and Jingkang Shen^1,*

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P.R. China ² The National Center for Drug Screening, 189 Guoshoujing Road, Shanghai 201203, P.R. China

* Author to whom correspondence should be addressed.

Received: 27 November 2006; in revised form: 17 December 2006 / Accepted: 18 December 2006 / Published: 21 December 2006

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Abstract: A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.

Keywords: Microwave irradiation; nucleophilic substitution; 6-substituted quinoxalines; JSP-1.

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MDPI and ACS Style

Zhang, L.; Qiu, B.; Li, X.; Wang, X.; Li, J.; Zhang, Y.; Liu, J.; Li, J.; Shen, J. Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution. Molecules 2006, 11, 988-999.

AMA Style

Zhang L, Qiu B, Li X, Wang X, Li J, Zhang Y, Liu J, Li J, Shen J. Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution. Molecules. 2006; 11(12):988-999.

Chicago/Turabian Style

Zhang, Li; Qiu, Beiying; Li, Xin; Wang, Xin; Li, Jingya; Zhang, Yongliang; Liu, Jian; Li, Jia; Shen, Jingkang. 2006. "Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution." Molecules 11, no. 12: 988-999.

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