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Open AccessCommunication
Molecules 2006, 11(12), 968-977; doi:10.3390/11120968

Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

1
Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy
2
Dipartimento di Chimica, Università di Sassari and local INSTM Research Unit, Via Vienna 2, 07100 Sassari, Italy
*
Author to whom correspondence should be addressed.
Received: 25 October 2006 / Revised: 8 December 2006 / Accepted: 15 December 2006 / Published: 18 December 2006
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Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.
Keywords: Hyperbranched polymers; AB2 monomers; DHICA; HIV-1; antiviral agents. Hyperbranched polymers; AB2 monomers; DHICA; HIV-1; antiviral agents.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sechi, M.; Casu, F.; Campesi, I.; Fiori, S.; Mariani, A. Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid. Molecules 2006, 11, 968-977.

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