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Molecules 2006, 11(12), 968-977; doi:10.3390/11120968
Communication

Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

1,* , 1, 1, 2 and 2
1 Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy 2 Dipartimento di Chimica, Università di Sassari and local INSTM Research Unit, Via Vienna 2, 07100 Sassari, Italy
* Author to whom correspondence should be addressed.
Received: 25 October 2006 / Revised: 8 December 2006 / Accepted: 15 December 2006 / Published: 18 December 2006
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Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.
Keywords: Hyperbranched polymers; AB2 monomers; DHICA; HIV-1; antiviral agents. Hyperbranched polymers; AB2 monomers; DHICA; HIV-1; antiviral agents.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sechi, M.; Casu, F.; Campesi, I.; Fiori, S.; Mariani, A. Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid. Molecules 2006, 11, 968-977.

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