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• Sechi, M
• Casu, F
• Campesi, I
• Fiori, S
• Mariani, A
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• Sechi, M
• Casu, F
• Campesi, I
• Fiori, S
• Mariani, A
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• Sechi, M
• Casu, F
• Campesi, I
• Fiori, S
• Mariani, A

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Molecules 2006, 11(12), 968-977; doi:10.3390/11120968

Communication

Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Mario Sechi ^1,* , Fabio Casu ¹ , Ilaria Campesi ¹ , Stefano Fiori ²  and Alberto Mariani ²

¹ Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy ² Dipartimento di Chimica, Università di Sassari and local INSTM Research Unit, Via Vienna 2, 07100 Sassari, Italy

* Author to whom correspondence should be addressed.

Received: 25 October 2006; in revised form: 8 December 2006 / Accepted: 15 December 2006 / Published: 18 December 2006

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Abstract: In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.

Keywords: Hyperbranched polymers; AB2 monomers; DHICA; HIV-1; antiviral agents.

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