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Molecules 2006, 11(11), 849-857; doi:10.3390/11110849

Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives

1
State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. ChinaState Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China
2
Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim, Xinjiang, P.R. China
*
Authors to whom correspondence should be addressed.
Received: 27 September 2006 / Revised: 26 October 2006 / Accepted: 27 October 2006 / Published: 2 November 2006
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Abstract

A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 than the reference compound etoposide. In addition, the partition coefficients (P) of all the new and previously synthesized derivatives were determined. View Full-Text
Keywords: 4'-Demethylepipodophyllotoxin; 5-fluorouracil; anticancer activities; partition coefficients 4'-Demethylepipodophyllotoxin; 5-fluorouracil; anticancer activities; partition coefficients
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, F.-M.; Yao, X.-J.; Tian, X.; Tu, Y.-Q. Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives. Molecules 2006, 11, 849-857.

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