Molecules 2006, 11(11), 849-857; doi:10.3390/11110849
Article

Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives

Fu-Min Zhang 1 email, Xiao-Jun Yao 1 email, Xuan Tian 1,* email and Yong-Qiang Tu 1,* email
1 State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. ChinaState Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China 2 Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim, Xinjiang, P.R. China
* Authors to whom correspondence should be addressed.
Received: 27 September 2006; in revised form: 26 October 2006 / Accepted: 27 October 2006 / Published: 2 November 2006
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Abstract: A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 and A549 than the reference compound etoposide. In addition, the partition coefficients (P) of all the new and previously synthesized derivatives were determined.
Keywords: 4'-Demethylepipodophyllotoxin; 5-fluorouracil; anticancer activities; partition coefficients

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MDPI and ACS Style

Zhang, F.-M.; Yao, X.-J.; Tian, X.; Tu, Y.-Q. Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives. Molecules 2006, 11, 849-857.

AMA Style

Zhang F-M, Yao X-J, Tian X, Tu Y-Q. Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives. Molecules. 2006; 11(11):849-857.

Chicago/Turabian Style

Zhang, Fu-Min; Yao, Xiao-Jun; Tian, Xuan; Tu, Yong-Qiang. 2006. "Synthesis and Biological Evaluation of New 4β-5-Fu-substituted 4'-Demethylepipodophyllotoxin Derivatives." Molecules 11, no. 11: 849-857.

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