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Molecules 2005, 10(9), 1153-1160; doi:10.3390/10091153

Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid

Department of Chemistry, College of Science, Al-Mustansirya University, Baghdad, Iraq
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Received: 29 June 2005 / Revised: 29 August 2005 / Accepted: 30 August 2005 / Published: 30 September 2005
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Abstract

New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.
Keywords: Bis-thiadiazolylcyclopropane; bis–triazolylcyclopropane; azomethines; Mannich bases. Bis-thiadiazolylcyclopropane; bis–triazolylcyclopropane; azomethines; Mannich bases.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sharba, A.; Al-Bayati, R.; Rezki, N.; Aouad, M. Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid. Molecules 2005, 10, 1153-1160.

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