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Molecules 2005, 10(9), 1153-1160; doi:10.3390/10091153
Article

Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid

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Received: 29 June 2005; in revised form: 29 August 2005 / Accepted: 30 August 2005 / Published: 30 September 2005
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Abstract: New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.
Keywords: Bis-thiadiazolylcyclopropane; bis–triazolylcyclopropane; azomethines; Mannich bases. Bis-thiadiazolylcyclopropane; bis–triazolylcyclopropane; azomethines; Mannich bases.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sharba, A.; Al-Bayati, R.; Rezki, N.; Aouad, M. Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid. Molecules 2005, 10, 1153-1160.

AMA Style

Sharba A, Al-Bayati R, Rezki N, Aouad M. Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid. Molecules. 2005; 10(9):1153-1160.

Chicago/Turabian Style

Sharba, A.; Al-Bayati, R.; Rezki, N.; Aouad, M. 2005. "Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid." Molecules 10, no. 9: 1153-1160.



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