Molecules 2005, 10(9), 1126-1134; doi:10.3390/10091126
Article

New Multi-1,2,3-Selenadiazole Aromatic Derivatives

M. Al-Smadi* email and S. Ratrout
Department of Applied Chemical Sciences, Jordan University of Science and Technology, Jordan
* Author to whom correspondence should be addressed.
Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005
(This article belongs to the Special Issue Selected Papers from the “2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry”)
PDF Full-text Download PDF Full-Text [152 KB, uploaded 20 June 2008 16:49 CEST]
Abstract: The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the corresponding semicarbazones derivatives 4a-d or hydrazones 5a-d. The reaction with selenium dioxide leads to regiospecific ring closure of semicarbazones or hydrazones to give the multi- 1,2,3-selenadiazole aromatic derivatives in high yield.
Keywords: 1; 2; 3-Selenadiazoles; semicarbazones; aromatic derivatives

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Al-Smadi, M.; Ratrout, S. New Multi-1,2,3-Selenadiazole Aromatic Derivatives. Molecules 2005, 10, 1126-1134.

AMA Style

Al-Smadi M, Ratrout S. New Multi-1,2,3-Selenadiazole Aromatic Derivatives. Molecules. 2005; 10(9):1126-1134.

Chicago/Turabian Style

Al-Smadi, M.; Ratrout, S. 2005. "New Multi-1,2,3-Selenadiazole Aromatic Derivatives." Molecules 10, no. 9: 1126-1134.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert