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Molecules 2005, 10(9), 1135-1144; doi:10.3390/10091135
Article

Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)

1,* , 1, 1, 1, 2 and 2
1 Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences, Georgia 2 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia
* Author to whom correspondence should be addressed.
Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005
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Abstract

Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], according to IR and NMR spectroscopy. The Symphytum high-molecular preparations can modulate in vitro B- chronic lymphocytic leukaemia (B-CLL) cells apoptosis and cell cycle progression.
Keywords: Caffeic acid; 3-(3; 4-dihydroxyphenyl)glyceric acid; Symphytum asperum; Symphytum asperum caucasicum; poly[oxy-1-carboxy-2-(3; 4-dihydroxyphenyl)ethylene]. Caffeic acid; 3-(3; 4-dihydroxyphenyl)glyceric acid; Symphytum asperum; Symphytum asperum caucasicum; poly[oxy-1-carboxy-2-(3; 4-dihydroxyphenyl)ethylene].
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Barbakadze, V.; Kemertelidze, E.; Targamadze, I.; Mulkijanyan, K.; Shashkov, A.; Usov, A. Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae). Molecules 2005, 10, 1135-1144.

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