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Towards a Synthesis of Vigabatrin Using Glycal Chemistry
Department of Chemistry, Indian Institute of Technology, Madras, India
* Author to whom correspondence should be addressed.
Received: 24 October 2004; in revised form: 8 December 2004 / Accepted: 7 January 2005 / Published: 31 August 2005
Abstract: Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored.
Keywords: Vigabatrin; GABA-T; γ-aminobutyric acid; 4-amino-5-hexenoic acid; Ferrier rearrangement; glycal.
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MDPI and ACS Style
Boga, S.; Aidhen, J.; Aidhen, I. Towards a Synthesis of Vigabatrin Using Glycal Chemistry. Molecules 2005, 10, 871-883.
Boga S, Aidhen J, Aidhen I. Towards a Synthesis of Vigabatrin Using Glycal Chemistry. Molecules. 2005; 10(8):871-883.
Boga, S.; Aidhen, J.; Aidhen, I. 2005. "Towards a Synthesis of Vigabatrin Using Glycal Chemistry." Molecules 10, no. 8: 871-883.