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Molecules 2005, 10(8), 871-883; doi:10.3390/10080871

Towards a Synthesis of Vigabatrin Using Glycal Chemistry

Department of Chemistry, Indian Institute of Technology, Madras, India
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Author to whom correspondence should be addressed.
Received: 24 October 2004 / Revised: 8 December 2004 / Accepted: 7 January 2005 / Published: 31 August 2005
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Abstract

Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S)- vigabatrin has been explored. View Full-Text
Keywords: Vigabatrin; GABA-T; γ-aminobutyric acid; 4-amino-5-hexenoic acid; Ferrier rearrangement; glycal. Vigabatrin; GABA-T; γ-aminobutyric acid; 4-amino-5-hexenoic acid; Ferrier rearrangement; glycal.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Boga, S.; Aidhen, J.; Aidhen, I. Towards a Synthesis of Vigabatrin Using Glycal Chemistry. Molecules 2005, 10, 871-883.

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